Enbrel (etanercept) is a medication used in Australia to treat autoimmune conditions like rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.

It is usually self-administered as an injection, either with a prefilled syringe or the SureClick pen. If you're new to Enbrel or need a refresher, this guide will walk you through the process step by step.

Note: This guide does not replace the manufacturer's instructions for use or your doctor's advice. It is a brief reminder. For more details or personalised advice, ask your doctor or pharmacist or refer to the manufacturer leaflet.

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Related article: How to store Your Enbrel (Etanercept) Injections Correctly at Home.

Before Injecting Enbrel

Before injecting Enbrel, it's essential to follow proper preparation steps to ensure safety and effectiveness. While the injection process is farily easy and will quickly become part of your routine, taking the time to prepare correctly can help minimise discomfort and reduce the risk of complications during the injection.

1. Gather Your Injection Supplies

You'll need:

  • Your Enbrel prefilled syringe or SureClick pen
  • An alcohol swab to disinfect the injection site
  • A cotton ball or gauze pad to apply gentle pressure after injection
  • A sharps disposal container to safely discard used needles and pens
  • A clean, well-lit space with a stable surface to set up your materials

Ensure all supplies are within reach before you begin, and check that your Enbrel pen or syringe is within its expiry date!

2. Wash Your Hands

Proper hand hygiene helps prevent infection. Wash your hands thoroughly with soap and warm water for at least 20 seconds. Dry them with a clean towel or allow them to air dry. If soap and water are unavailable, use an alcohol-based hand sanitiser.

3. Choose Your Injection Site

Enbrel is usually injected into the stomach (at least 5 cm away from the belly button) or the front of the thigh. Alternate between injection sites for each injection to prevent irritation and avoid injecting into the same spot repeatedly.

If you have a caregiver administering the injection, they may also use the outer area of the upper arms. Avoid areas that are bruised, red, tender, or scarred from previous injections.

Gently feel the area to ensure there are no hard lumps, which could indicate previous irritation or improper healing from past injections. If necessary, consult your healthcare provider about the best sites for your injections.

Related article: How to Travel With Enbrel Injections: Tips on Travel Kits, Packing for Air Travel, Crossing International Borders, and More!

How to Inject Enbrel Prefilled Syringes

Enbrel prefilled syringes are designed for single-use injections and contain a pre-measured dose of medication. They require manual injection, making it important to handle them with care.

If you are nervous about self-injecting, you can practice using a dummy syringe (available from your healthcare provider) before your first real injection.

Note: This is just a brief summary of each step. For more details, refer to the manufacturer's instructions and make sure to read them at least once in full detail before injecting. If you have doubt or feel uncomfortable, ask for your doctor or pharmacist's advice.

1. Check the Syringe

Remove the syringe from the fridge and allow it to reach room temperature for about 15 to 30 minutes.

  • Do not shake the syringe.
  • Check the liquid inside-it should be clear and free of particles.

2. Prepare the Injection Site

Wipe the chosen area with an alcohol swab and let it dry completely.

3. Inject the Medication

  • Remove the needle cap.
  • Hold the syringe at a 45-degree angle.
  • Pinch the skin slightly and insert the needle fully.
  • Press the plunger slowly to inject the medication.
  • Remove the needle at the same angle and release the skin.

4. Dispose of the Syringe

Place the used syringe in a sharps container immediately. Do not reuse or recap the needle.

Related article: Travelling with Arthritis: Here's What to Know for a Safe and Comfortable Trip!

How to Inject Enbrel SureClick Pen

The SureClick auto-injector is designed for easier administration and is a good option for those who may be uncomfortable with using a traditional syringe. It delivers a pre-measured dose with minimal effort, making the injection process quick and straightforward. Here's how to use it:

Note: This is just a brief summary of each step. For more details, refer to the manufacturer's instructions and make sure to read them at least once in full detail before injecting. If you have doubt or feel uncomfortable, ask for your doctor or pharmacist's advice.

1. Check the SureClick Pen

Take the pen out of the fridge and let it warm to room temperature for at least 30 minutes. Inspect the liquid to ensure it is clear.

2. Prepare the Skin

Clean the injection site with an alcohol swab and let it dry.

3. Inject Using the SureClick Pen

  • Remove the cap.
  • Stretch your skin at the injection site.
  • Hold the pen firmly against the skin at a 90-degree angle.
  • Press the purple injection button.
  • You'll hear a click, which signals that the injection has started.
  • Keep pushing the button and hold for 15 seconds.
  • You may hear a second click indicating the injection has completed.
  • Check that the viewing window turns from clear to yellow.
  • Remove the injector pen from your skin.

4. Dispose of the Pen

Immediately discard the used SureClick pen in a sharps disposal container. Do not throw away in household trash bins.

Common Mistakes to Avoid When Injecting Enbrel

Making mistakes during the injection process can lead to discomfort, reduced effectiveness of the medication, or even minor injuries. By being aware of common pitfalls, you can ensure a smoother experience and better treatment outcomes.

ā„ļø Skipping the warming step: Injecting cold Enbrel straight from the fridge can be uncomfortable and cause the injection to take more time. Allowing the medication to reach room temperature for at least 30 minutes before injecting can help reduce discomfort.

ā³ Not allowing your skin to dry: Injecting into wet skin can cause stinging and irritation. After swabbing the injection site, wait a few moments until the area is completely dry before proceeding.

šŸ”„ Using the same injection site repeatedly: Injecting in the same spot too often can lead to skin irritation, hard lumps, or tissue damage. Rotate between recommended injection sites, such as the thighs and stomach (avoiding the navel area), to promote healing and reduce discomfort.

šŸ’‰ Incorrect injection angle or depth: Using the wrong injection technique can lead to discomfort or ineffective medication absorption. Be sure to follow the manufacturer's instructions closely and ask your healthcare provider for guidance if needed.

šŸƒ Rushing the process: Taking your time during the injection process can help minimise mistakes and discomfort. Ensure you follow all the necessary steps carefully, from preparation to disposal.

Related article: Can You Fly With Arthritis and How to Manage Your Symptoms During Long-Haul Flights?

We'd love to hear your thoughts!

šŸ’¬ If you have any questions, experiences, or tips about injecting Enbrel, feel free to share them in the comments below. Your insights can help others who are also navigating this process.

February 02, 2025

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The information presented in this article and its comment section is for informational purposes only and is not intended as a replacement for professional medical advice. Always consult with a qualified healthcare provider for any medical concerns or questions you may have.